This article theorizes and introduces Episto-Musical Pedagogy Theory as a transformative Afrocentric framework for decolonizing African education through the integration of Indigenous musical epistemologies. In alignment with Sustainable Development Goal 4 (Quality Education), the study responds to the systemic marginalization of African knowledge systems, particularly musical traditions, within formal curricula dominated by Eurocentric paradigms. This curricular imbalance, especially evident in Nigeria, perpetuates cognitive injustice and erodes cultural identity. Developed by Albert Authority, Episto-Musical Pedagogy Theory redefines music as a sovereign epistemological system rooted in African ontologies. It positions rhythm, narrative, and performance not as pedagogical supplements but as foundational tools for transmitting ethical, historical, and cosmological wisdom. The theory challenges prevailing educational models by asserting music’s capacity to preserve and regenerate Indigenous knowledge across generations. Methodologically, the article employs interdisciplinary literature synthesis, cultural exemplars, and comparative analysis, engaging the lived experiences of educators, curriculum designers, and Indigenous knowledge custodians. This approach illuminates how African musical practices function as dynamic vehicles of instruction, communal memory, and epistemic agency. Key arguments emphasize the theory’s potential to dismantle curricular coloniality, reimagine pedagogy, and restore cultural sovereignty. By foregrounding music as a legitimate mode of knowing, the article contributes to scholarship in music education, decolonial studies, and Indigenous epistemology. It concludes with implications for curriculum reform, teacher training, and policy development, advocating for the intentional integration of music-based Indigenous knowledge as a pathway toward cognitive justice, cultural relevance, and educational transformation.