Global Research Society Publisher

GRS Journal of Multidisciplinary Research and Studies

All Issues

1. Biotechnological Approaches in the Detection, Control, and Prevention...
7

Dr. Anjali Maria*, Dr. Mercy j...
First year junior resident Dept .of microbiology Pushpagiri institute of medical sciences and research Centre, thiruvalla, Pathanamthitta, kerala.
1-8
https://doi.org/10.5281/zenodo.21023699

Background- Candida auris is an emerging multidrug-resistant (MDR) fungal pathogen that poses a significant global health threat, particularly in healthcare settings. Its ability to cause invasive infections, coupled with its resistance to multiple antifungal drugs and propensity for hospital outbreaks, necessitates rapid and accurate diagnostic and control strategies. Aim- This report aims to comprehensively review the biotechnological approaches employed in the rapid detection, effective control, and proactive prevention of C. auris infections. A particular focus will be placed on CRISPR-based diagnostic methods and novel biotechnological interventions for managing this formidable pathogen. Methodology- Conventional diagnostic methods for C. auris often suffer from limitations such as prolonged turnaround times and misidentification issues. The advent of molecular diagnostics, including PCR, sequencing, and MALDI-TOF, has significantly improved detection capabilities. Among these, CRISPR technology has emerged as a highly promising tool for rapid, sensitive, and specific C. auris detection. Systems like SHERLOCK and DETECTR, utilizing Cas12 and Cas13 enzymes, offer point-of-care potential and the ability to detect resistance genes. Beyond diagnostics, biotechnological strategies for control and prevention involve the development of novel antifungal compounds, nanotechnology-based solutions such as antifungal coatings and targeted nanoparticles, and CRISPR-based gene editing for identifying therapeutic targets. These innovations are crucial for mitigating the spread and impact of C. auris. Conclusion- CRISPR-based diagnostic approaches represent a significant advancement in the rapid and accurate identification of C. auris, facilitating timely intervention and outbreak control. Coupled with other biotechnological innovations in prevention and control, these strategies are poised to revolutionize the management of this challenging fungal pathogen, ultimately improving patient outcomes and public health safety.

2. Design and Development, of a Faculty Personal Professional Development...
3

Shahid Hassan*, Syed Mustafa K...
Academic Office, Dean’s Office and Department of Anatomy.
9-17
https://doi.org/10.5281/zenodo.21023816

Background- Faculty development is a critical determinant of educational quality, curriculum effectiveness, and institutional success in medical education. Despite substantial investments in faculty development activities, many institutions continue to employ fragmented approaches that are not systematically aligned with faculty needs, institutional priorities, or curriculum quality improvement initiatives. To address this challenge, the American University of Barbados School of Medicine (AUB-SOM) designed and development of Faculty Personal Professional Development Plan (PPDP) integrated with a needs assessment process to support individual faculty growth while simultaneously informing institutional planning and curriculum continuous quality improvement (CQI). Objective- To describe the design, development, and anticipated institutional impact of a Faculty Personal Professional Development Plan framework linked to faculty needs assessment, faculty development programming, institutional effectiveness, and curriculum CQI. Methods- A developmental and quality improvement project was conducted using a structured systems-based approach. The PPDP framework was designed through review of faculty development literature, accreditation standards, institutional strategic priorities, and stakeholder consultation. To identify faculty development needs related to the PPDP framework, a structured needs assessment survey was administered to all faculty members. The survey evaluated faculty knowledge, perceptions, and self-reported competencies regarding various aspects of professional development planning, including goal setting, reflective practice, documentation of evidence, appraisal processes, career advancement, and the role of PPDP in institutional effectiveness and curriculum CQI. The items on quantitative and qualitative responses were reviewee to determine areas of knowledge deficiency and professional development priorities. The identified gaps served as the basis for developing targeted faculty development interventions and establishing an annual faculty development agenda aligned with institutional quality improvement goals. The survey was provided with file uploading option of submitting the completed PPDP form sent via individual faculty email address. Results- The PPDP framework facilitated systematic identification of faculty development needs across educational, scholarly, leadership, technological, and clinical domains. The process established a mechanism for aligning individual faculty goals with institutional objectives and provided actionable information for faculty development planning, curriculum review, and quality assurance activities. The model created an institutional feedback loop linking faculty growth with educational quality, curriculum enhancement and achievement of institutional mission while meeting the accreditation standards. Conclusion- The PPDP framework represents a practical and scalable strategy for integrating faculty development, institutional effectiveness, and curriculum CQI. The approach offers medical schools a sustainable mechanism for evidence-informed faculty development and continuous organizational improvement.

3. Climate-Smart Agricultural Technology Adoption and Intensity among Veg...
6

Sibandze Sikelela. S*., Olarin...
Department of Agricultural Economics and Management, P.O. Box Luyengo, Luyengo, University of Eswatini, Eswatini.
18-30
https://doi.org/10.5281/zenodo.21023956

Problem and Objectives: Trends reveal that in Eswatini, there are low quantities of vegetables produced locally and statistics show more volumes of vegetable imports which constitute about 70% of local consumption as a result of local production failing to meet domestic demand. The main objective of this study was to determine the factors affecting Climate Smart Agricultural Technology (CSAT) adoption and intensity among vegetable farmers in Eswatini. Methods: The study used a descriptive quantitative research design to determine the factors affecting the adoption and intensity of adoption of climate-smart agriculture technology among smallholder vegetable farmers. A total of 200 vegetable farmers were purposively sampled from a population of 946 vegetable farmers registered with The National Marketing Board (NAMBoard) and were part of the Market Oriented Climate-Smart Agriculture Project. The study used survey to collect primary data through the use of a questionnaire. Data were analysed using descriptive statistics, and Cragg Double Hurdle model. The dependent variables of the model were adoption of CSAT and intensity of CSAT adoption. Adoption of CSAT was measured as a binary variable (1= adopter, 0 = non-adopter) and intensity of adoption of CSAT was measured as a proportion of adopted CSATs given the available CSATs. Findings: The findings of the study indicate that significant factors affecting CSAT adoption decision include age, risk attitude, household size, off-income, and land quality. The results on factors affecting the intensity of CSAT adoption reveal that the adoption intensity is affected by age, access to inputs market, farm size, land quality and frequency of extension contact. Conclusion and Recommendations: The study examined the factors affecting adoption and intensity of adoption of CSAT among vegetable farmers. The findings indicate that CSAT adoption decision depend on access and awareness while CSAT adoption intensity is constrained by structural and institutional factor. The study recommends that more training be undertaken to sensitize farmers to adopt more CSAT and increase awareness of CSAT. It is recommended that the Ministry of Agriculture and the National Agricultural Marketing Board (NAMBoard) improve its extension services, capacitation of farmers through CSA workshop and diversify CSA interventions to other enterprises.

4. Statistical Analysis of the Geological Texture and Environmental Pollu...
2

Changde Andrew Nanfa, Ajare Em...
Department of Geology, Federal University Lokoja, Nigeria.
31-37
https://doi.org/10.5281/zenodo.21024068

This study examines the statistical analysis of the geological texture and environmental pollution, impact caused by urbanization on students of Federal University Lokoja, Kogi State. Rising percentage of people is living in settlements classified as urban regions, a phenomenon known as urbanization. It typically comes from a natural growth (the excess of births over deaths) or the net migration of individuals from rural to urban regions. However, depending on the criteria applied, different countries have different definitions of what constitutes an urban center. This over congestion in Lokoja is popularly found along Felele express road which had caused serious damage to the road texture and had resulted into multiple accidents that claims life of students of Federal University Lokoja. The rampant accident that claims life and properties along felele Lokoja express road is attributed to the geological effect and Urbanization, a hallmark of development, is rapidly transforming Lokoja, the capital of Kogi State into mega state like Lagos, road is becoming extremely busy, dangerous and congested. Accidents on Lokoja felele road is becoming rampant as while as air pollution by smokes and dangerous exhaust released by moving trucks day and night which affects more and larger crowd than. Effect of geological texture and environmental on road texture (felele express road). The study concluded that statistically that road damage and air pollution has effect on resident health status. The relationship of the effect between road damage/ air pollution and resident health status is statistically significant according to the observation from the respondent’s response. And some recommendation is put forward which includes restructure of Abuja Lokoja Felele Road. The study recommends that more training be undertaken to sensitize farmers to adopt more CSAT and increase awareness of CSAT. It is recommended that the Ministry of Agriculture and the National Agricultural Marketing Board (NAMBoard) improve its extension services, capacitation of farmers through CSA workshop and diversify CSA interventions to other enterprises.

5. Statistical Analysis of Cybercrime Participation among Undergraduate S...
4

Israel Nandi Bigun*, Ajare Emm...
Federal University Lokoja, Nigeria.
38-44
https://doi.org/10.5281/zenodo.21024168

This study seeks to examine the prevalence and determinants of cybercrime participation among undergraduate students of mass communication in federal university Lokoja. The ultimate goal is to foster a safer digital environment within the university community while promoting ethical digital practices among students. Using the Edwin Sutherland’s Differential Association Theory and Albert Bandura’s Social Learning Theory which provided a nexus between social/digital interaction and learning/adoption of deviant behavior, the study adopted descriptive survey. The finding shows that 100-level students recorded the highest cybercrime participation rate (72%), followed by 200-level (69%). Findings also revealed that peer influence significantly influences cybercrime participation among students and that the significant influence of peers' financial gains on students' interest in cybercrime, indicate that economic pressure is a key factor. The study therefore recommends among other things, the introduction of mandatory first-year cybersecurity education and increased structured academic engagement to reduce idle time and prevent early student involvement in cybercrime. The study also recommends the integration of compulsory cyber ethics and legal awareness courses across all levels while fostering collaboration among institutions, private sector, and government to provide scholarships that alleviate financial pressures and discourage student involvement in cybercrime.

6. Role of Ultrasonography and Colour Doppler in Evaluation of Thyroid No...
0

Dr.Sanjay N. Totawar*, Dr.Sati...
Resident, Department of Radiodiagnosis, IGGMC, Nagpur – 440018
45-58
https://doi.org/10.5281/zenodo.21024350

Background & Aim: Thyroid nodules represent one of the most prevalent endocrinological findings in clinical practice, with sonographic prevalence ranging from 19–67%. The principal diagnostic challenge lies in non-invasively differentiating malignant from the far more prevalent benign thyroid nodules. This study aimed to systematically evaluate the gray scale, color Doppler flow imaging (CDFI), and spectral Doppler characteristics of thyroid nodules and to correlate these sonographic features with fine needle aspiration cytology (FNAC) findings. Methods: This prospective, descriptive cross-sectional study was conducted at the Department of Radiodiagnosis, IGGMC, Nagpur, over a 24-month period (November 2017 – November 2019). Eighty consecutive patients presenting with thyroid swelling underwent high-resolution grayscale ultrasonography and color/spectral Doppler evaluation using a Philips HD11XE machine with a 7–12 MHz linear transducer. Nodule characteristics assessed included size, shape, echotexture, margins, halo, internal calcification, cervical lymphadenopathy, and vascularity (CDFI). Spectral Doppler parameters including peak systolic velocity (PSV), pulsatility index (PI), and resistive index (RI) were recorded. Nodules were stratified using the Thyroid Imaging Reporting and Data System (TI-RADS). All cases subsequently underwent USG-guided FNAC, and histopathological biopsy where applicable. Statistical analysis was performed using chi-square test and receiver operating characteristic (ROC) curve analysis; p < 0.05 was considered statistically significant. Results: Of 80 patients (78.75% female; mean age 38.4 years), 71 (88.75%) harbored benign and 9 (11.25%) malignant nodules. Malignant lesions were significantly more frequent in patients aged >40 years (p < 0.001). On gray scale, irregular margins (88.89% vs 0%), hypoechogenicity (77.78% vs 8.45%), and the presence of microcalcifications (77.78% vs 42.25%) were strongly associated with malignancy (all p < 0.05). On CDFI, intra-nodular vascularity was present in 100% of malignant versus 19.71% of benign lesions (p < 0.001). Spectral Doppler demonstrated RI > 0.75 in 88.89% of malignant nodules (sensitivity 88.89%, specificity 98.59%; p < 0.001) and PSV ≤ 20.4 cm/s in 100% of malignant lesions (p < 0.001). Combined gray scale + Doppler sonography achieved an overall sensitivity of 98% and specificity of 97% for detection of thyroid malignancy. Complete concordance was achieved between USG and FNAC diagnoses for all malignant lesions. Among malignant lesions, papillary thyroid carcinoma and follicular thyroid carcinoma were the most common histotypes, each accounting for 33.33% (3/9 cases), followed by anaplastic carcinoma (22.22%) and medullary carcinoma (11.11%). Conclusion: High-resolution gray scale ultrasonography combined with CDFI and pulse Doppler constitutes a highly sensitive, non-invasive first-line imaging modality for characterizing thyroid nodules. The combination achieves near-complete correlation with FNAC for malignant lesions, potentially reducing the need for unnecessary cytological sampling in clinically benign lesions.





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