Introduction: The prevention of smoking in adolescence is a vital aspect of public health policy. Given that smoking behavior often begins during the teenage years, early and comprehensive intervention is essential. Purpose: This paper investigates the effectiveness of anti-smoking educational programs in preventing smoking behavior among young people. Methodology: A bibliographical search of retrospective and investigative studies, which were drawn from the Medline, PubMed and Cinahl databases, as well as the Greek Iatrotek database and scientific literature related to the matter, was utilized. Results: Despite growing public awareness and tobacco control policies, a significant number of adolescents initiate smoking before adulthood, increasing the risk of long-term addiction and chronic diseases. Drawing on behavioral theories, empirical studies, and best practices, the study highlights the critical role of schools in shaping healthy behaviors and implementing successful prevention strategies. School-based educational programs, informed by behavioral theories and supported by community collaboration, have demonstrated significant potential in reducing youth smoking rates. Conclusion: The findings underline the importance of early, comprehensive, and multi-dimensional interventions to reduce smoking rates in adolescence and promote a smoke-free future.